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What is the most potent opioid used commercially?

Carfentanil or carfentanyl (Wildnil) is an analogue of the popular synthetic opioid analgesic fentanyl, and is one of the most potent opioids known (also the most potent opioid used commercially). Carfentanil was first synthesized in 1974 by a team of chemists at Janssen Pharmaceutica which included Paul Janssen.

Carfentanil prices on the site and elsewhere online range from $800 to about $2,500 per gram, while a report last year from the Ohio Substance Abuse Monitoring Network found heroin for sale in the Cleveland area for roughly $90 to $120 per gram, and similar prices are available through the dark web

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In the past few months, a string of overdoses across the U.S. has been linked to an opioid drug so potent that it’s not intended for human consumption

Carfentanil is the world’s most powerful commercial opioid, considered to be 100 times more potent than its relative fentanyl, the carefully controlled prescription painkiller linked to Prince’s death, which itself is 50 times stronger than heroin.

Originally synthesized in the 1970s, carfentanil is marketed under the name Wildnil as a general anaesthetic for large animals like elephants, and was never intended for humans. But like any number of new synthetic drugs, it’s easily finding its way from clandestine labs and into the illicit drug supply through the mail. Sold openly on the web or through drug markets on the anonymous Tor network, the drug is being added to heroin and counterfeit pain medication by traffickers and often taken by users who don’t know exactly what they’re consuming.

“We’re seeing a lot of the activity take place over the internet through anonymous relationships between a consumer and the drug manufacturer or source of supply,” says Russ Baer, a spokesman for the Drug Enforcement Administration. The agency has warned communities across the country to be on alert for the drug, and has told first responders to wear protective gloves and masks, since the drug can be dangerous to someone who simply touches it.

In recent months, hundreds of drug overdoses have been linked to carfentanil and fentanyl, a related opioid said to be 100 times the strength of morphine and commonly used to treat severe pain in cancer patients. The drug has showed up on the Gulf Coast of Florida, in western Pennsylvania, central Kentucky, and in Ohio, where, in one county this August, at least 96 heroin users overdosed in a single week.

Synonyms
  • 4-carbomethoxy Fentanyl
  • Carfentanyl

Carfentanil (CAS 59708-52-0) is an analytical reference material that is structurally classified as an opioid. It is a derivative of fentanyl (Item Nos. ISO60197 | 14719) that potently binds to µ-opioid receptors with a Ki value of 24 pM.1 It is highly selective for the µ-opioid receptor, binding to δ- and κ-opioid receptors with Ki values of 3.28 and 43.1 nM, respectively.1 This product is intended for research and forensic applications.

This product is a qualified Reference Material (RM) that has been manufactured and tested to meet ISO17025 and Guide 34 guidelines. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability of measurements. All traceable RMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support.