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Description

U-47700 – B

ackgrounder

What is U-47700?

The drug U -47700 ( 3,4-Dichloro-N-[2 -(dimethylamino)cyclohexyl]-N-methylbenzamide) is a synthetic analgesic
opioid. It was first synthesized in 1978 by an employee of pharmaceutical manufacturer The Upjohn
Company. References to U
-47700 began appearing in academic literature in 1982, when research conducted
by Upjohn was first published
. U-
47700 normally appears as a white powder or a liquid and can be used
orally, intravenously, nasally, or inhaled
. “U4”
, “pink”, and
“fake morphine”
are common street names
for this
drug.
U-
47700 acts as an agonist on the mu
-opioid receptors in the
central nervous system. This causes effects
similar to other opioids such as euphoria, analgesia, and extreme sedation. It depresses the cough reflex, and
constricts pupils, and can suppress the respiratory system to potentially fatal levels. Users may als
o
experience itchiness
, drowsiness,
nausea,
cyanosis
, or constipation.
What is it used for?
Originally, U-
47700 was developed to be a non
-addicting analgesic as potent as morphine; however the drug
was never brought to market and has not been studied in
humans. There is little pharmacokinetic data
available and it is not approved for any medical use in humans
or veterinary practice
.

Why is it dangerous?

Production of
counterfeit
oxycodone pills has been increasing, some of which have contained
U-
47700. Many
of those who consume these pills may be unaware they are taking drugs other than oxycodone.
Studies have
shown U
-47700 to be 7.5 times more potent than morphine and as a result, a usual dosage may be more
likely to result in an overdose. Prol
onged use
can lead to
dependence and high doses of U
-47700 can result in
coma and death.
Before it was
listed in the Controlled Drugs and Substances Act in Canada, U-
47700 was easily accessible for
purchase online from various distributors of research ch
emicals.
In 2017, U
-47700 was detected in 223 drug
seizure
samples
provided to Health Canada’s Drug Analysis Service (DAS)
.
Fatalities and treatment
Current data on deaths in Alberta linked to U-
47700 overdoses i
s not available
; however,
there were five
Canadian deaths reported in the media due to U
-47700 between 2016 and 2017.
In case studies and user
reports, naloxone has been shown to reverse U
-47700 overdoses; however, there is currently no approved
reversal agent. Because U
-47700 use in humans has not been studied, the dose of naloxone required to
reverse an overdose may be different than the dose required for other opioid overdoses such as morphine or
fentanyl